Reaction: Glasdegib to 1 product
- Reaction
- Reaction type
- demethylation
- Direction
- Not Available
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- active
- References
- Lam JL, Vaz A, Hee B, Liang Y, Yang X, Shaik MN: Metabolism, excretion and pharmacokinetics of [(14)C]glasdegib (PF-04449913) in healthy volunteers following oral administration. Xenobiotica. 2017 Dec;47(12):1064-1076. doi: 10.1080/00498254.2016.1261307. Epub 2017 Jan 3. [Article]
- EMA Assessment Report: Daurismo International non-proprietary name glasdegib [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A4 Not Available Not Available implied