Reaction: Tamoxifen to 1 product

Reaction
Tamoxifen
DB00675
Tamoxifen N-oxide
DBMET00032
Reaction type
N-oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Squirewell EJ, Qin X, Duffel MW: Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50. doi: 10.1124/dmd.114.059709. Epub 2014 Aug 25. [Article]
  2. White IN: The tamoxifen dilemma. Carcinogenesis. 1999 Jul;20(7):1153-60. doi: 10.1093/carcin/20.7.1153. [Article]
  3. Parte P, Kupfer D: Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin. Drug Metab Dispos. 2005 Oct;33(10):1446-52. doi: 10.1124/dmd.104.000802. Epub 2005 Jun 29. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Dimethylaniline monooxygenase [N-oxide-forming] 1Not AvailableNot Availableimplied
Dimethylaniline monooxygenase [N-oxide-forming] 3Not AvailableNot Availableimplied