Flavin-containing monooxygenase 1

BE0003609ProteinHumansFMO1

Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:32156684). It is acted on by 13 drugs in DrugBank.

Gene name
FMO1
UniProtKB entry
Q01740Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
532 residues · 60,310 Da
Also known as
1.14.13.148 · 1.14.13.8 · Dimethylaniline monooxygenase [N-oxide-forming] 1 · Dimethylaniline oxidase 1 · Fetal hepatic flavin-containing monooxygenase 1

Resolves to

Protein
UniProtQ01740UniProt nameFMO1_HUMAN
Gene
HGNCHGNC:3769NCBI Gene2326GenBank182671GeneCardsFMO1
Pharmacology
KEGGhsa:2326
Drugs

What you can answer from here — as of September 03, 2024

13DrugsApproved to experimental, with action, bond type and pharmacological action
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5Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Flavin-containing monooxygenase 1, how selective are they, and which programs against it are still in active trials?

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