Flavin-containing monooxygenase 3

BE0003606ProteinHumansFMO3

Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441, PubMed:32156684). It is acted on by 21 drugs in DrugBank.

Gene name
FMO3
UniProtKB entry
P31513Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
532 residues · 60,033 Da
Also known as
1.14.13.148 · 1.14.13.32 · 1.14.13.8 · Dimethylaniline monooxygenase [N-oxide-forming] 3 · Dimethylaniline oxidase 3

Resolves to

Protein
UniProtP31513UniProt nameFMO3_HUMAN
Gene
HGNCHGNC:3771NCBI Gene2328GenBank188631GeneCardsFMO3
Pharmacology
KEGGhsa:2328
Drugs

What you can answer from here — as of September 03, 2024

21DrugsApproved to experimental, with action, bond type and pharmacological action
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15Metabolic reactionsDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Flavin-containing monooxygenase 3, how selective are they, and which programs against it are still in active trials?

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