Reaction: Carvedilol to 1 product

Reaction
Carvedilol
DB01136
Carvedilol Glucuronide
DBMET02722
Reaction type
O-glucuronidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Takekuma Y, Yagisawa K, Sugawara M: Mutual inhibition between carvedilol enantiomers during racemate glucuronidation mediated by human liver and intestinal microsomes. Biol Pharm Bull. 2012;35(2):151-63. doi: 10.1248/bpb.35.151. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 1-1Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 2B4Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 2B7Not AvailableNot Availableimplied