UDP-glucuronosyltransferase 1A1

BE0003541ProteinHumansUGT1A1

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:18004206,... It is acted on by 149 drugs in DrugBank.

Gene name
UGT1A1
UniProtKB entry
P22309Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
533 residues · 59,591 Da
Also known as
2.4.1.17 · Bilirubin-specific UDPGT isozyme 1 · GNT1 · hUG-BR1 · UDP-glucuronosyltransferase 1-1

Resolves to

Protein
UniProtP22309UniProt nameUD11_HUMAN
Gene
HGNCHGNC:12530NCBI Gene54658GenBank184473GeneCardsUGT1A1
Pharmacology
IUPHAR/GtoPdb2990KEGGhsa:54658
Drugs

What you can answer from here — as of September 03, 2024

149DrugsApproved to experimental, with action, bond type and pharmacological action
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52Clinical trialsTrials of drugs acting on it, by phase and status
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62Metabolic reactionsDrug transformations it catalyses, substrate to product
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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234+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 1A1, how selective are they, and which programs against it are still in active trials?

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