Reaction: Dorzolamide to 1 product
- Reaction
- Reaction type
- N-deethylation
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- active
- References
- Hasegawa T, Hara K, Kenmochi T, Hata S: In vitro metabolism of dorzolamide, a novel potent carbonic anhydrase inhibitor, in rat liver microsomes. Drug Metab Dispos. 1994 Nov-Dec;22(6):916-21. [Article]
- Balfour JA, Wilde MI: Dorzolamide. A review of its pharmacology and therapeutic potential in the management of glaucoma and ocular hypertension. Drugs Aging. 1997 May;10(5):384-403. [Article]
- FDA Approved Drug Products: TRUSOPT (dorzolamide hydrochloride) ophthalmic solution [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A2 Not Available Not Available implied Cytochrome P450 2B1 Not Available Not Available implied Cytochrome P450 2E1 Not Available Not Available implied
