Cytochrome P450 2E1

BE0003533ProteinHumansCYP2E1

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). It is acted on by 168 drugs in DrugBank.

Gene name
CYP2E1
UniProtKB entry
P05181Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
493 residues · 56,848 Da
Also known as
1.14.14.1 · 4-nitrophenol 2-hydroxylase · CYP2E · CYPIIE1 · Cytochrome P450-J

Resolves to

Protein
UniProtP05181UniProt nameCP2E1_HUMAN
Gene
HGNCHGNC:2631NCBI Gene1571GenBank181360GeneCardsCYP2E1
Pharmacology
IUPHAR/GtoPdb1330KEGGhsa:1571
Structure
PDB3E4EPDB3E6IPDB3GPH
Drugs

What you can answer from here — as of September 07, 2019

168DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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50Metabolic reactionsDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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311+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 2E1, how selective are they, and which programs against it are still in active trials?

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