Reaction: Leucovorin to 1 product

reductionMajor circulating metaboliteMetabolism of Leucovorin

Leucovorin is converted to 5-Methyltetrahydrofolate by 5-formyltetrahydrofolate cyclo-ligase and Methylenetetrahydrofolate reductase (NADPH).

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active

What you can answer from here — as of March 31, 2026

2EnzymesEach linked to its target card
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2ReferencesThe literature this reaction is curated from
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Which other drugs are metabolised by 5-formyltetrahydrofolate cyclo-ligase and Methylenetetrahydrofolate reductase (NADPH), and which of those pairings are clinically significant?

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