Methylenetetrahydrofolate reductase (NADPH)

BE0002176ProteinHumansMTHFR

Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine (PubMed:29891918). It is acted on by 10 drugs in DrugBank.

Gene name
MTHFR
UniProtKB entry
P42898Swiss-Prot
Residues / weight
656 residues · 74,596 Da
Also known as
1.5.1.53

Resolves to

Protein
UniProtP42898UniProt nameMTHR_HUMAN
Gene
HGNCHGNC:7436NCBI Gene4524GenBank6139053GeneCardsMTHFR
Pharmacology
KEGGhsa:4524
Structure
PDB6FCXPDB8QA4PDB8QA5
Drugs

What you can answer from here — as of September 03, 2024

10DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methylenetetrahydrofolate reductase (NADPH), how selective are they, and which programs against it are still in active trials?

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