Reaction: Ruxolitinib to 1 product

2-hydroxylationMajor circulating metaboliteMetabolism of Ruxolitinib

Ruxolitinib is converted to Ruxolitinib M18 metabolite by Cytochrome P450 3A4 and Cytochrome P450 2C9.

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active

What you can answer from here — as of February 24, 2021

2EnzymesEach linked to its target card
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3ReferencesThe literature this reaction is curated from
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Which other drugs are metabolised by Cytochrome P450 3A4 and Cytochrome P450 2C9, and which of those pairings are clinically significant?

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