Reaction: Ruxolitinib to 1 product
Ruxolitinib is converted to Ruxolitinib M16 metabolite by Cytochrome P450 3A4 and Cytochrome P450 2C9.
- Reaction
- Direction
- Activity
- active
- Comments
- M16 and M27, which are stereoisomers, are the main circulating metabolites in the plasma.
What you can answer from here — as of February 25, 2021
2EnzymesEach linked to its target cardListed above
Which other drugs are metabolised by Cytochrome P450 3A4 and Cytochrome P450 2C9, and which of those pairings are clinically significant?
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