Reaction: Pyridostigmine to 1 product

Reaction
Pyridostigmine
DB00545
3-hydroxy-N-methyl-pyridinium
DBMET03285
Reaction type
hydrolysis
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Aquilonius SM, Hartvig P: Clinical pharmacokinetics of cholinesterase inhibitors. Clin Pharmacokinet. 1986 May-Jun;11(3):236-49. doi: 10.2165/00003088-198611030-00005. [Article]
  2. Kornfeld P, Samuels AJ, Wolf RL, Osserman KE: Metabolism of 14C-labeled pyridostigmine in myasthenia gravis. Evidence for multiple metabolites. Neurology. 1970 Jul;20(7):634-41. doi: 10.1212/wnl.20.7.634. [Article]
  3. Somani SM, Roberts JB, Wilson A: Pyridostigmine metabolism in man. Clin Pharmacol Ther. 1972 May-Jun;13(3):393-9. doi: 10.1002/cpt1972133393. [Article]
  4. NIH: pyridostigmine bromide CSWG report [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
AcetylcholinesteraseNot AvailableNot Availableimplied
CholinesteraseNot AvailableNot Availableimplied