Reaction: Silodosin to 1 product

Reaction
Reaction type
dehydrogenation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
inactive
References
  1. Matsubara Y, Kanazawa T, Kojima Y, Abe Y, Kobayashi K, Kanbe H, Harada H, Momose Y, Terakado S, Adachi Y, Midgley I: [Pharmacokinetics and disposition of silodosin (KMD-3213)]. Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45. [Article]
  2. Vishnuvardhan C, Baikadi S, Borkar RM, Srinivas R, Satheeshkumar N: In vivo metabolic investigation of silodosin using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites. J Mass Spectrom. 2016 Oct;51(10):867-882. doi: 10.1002/jms.3795. [Article]
  3. FDA Approved Drug Products: RAPAFLO (silodosin) Capsule for oral use [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Alcohol dehydrogenase [NADP(+)]Not AvailableNot Availableconfirmed
Aldehyde dehydrogenase, mitochondrialNot AvailableNot Availableconfirmed