Aldo-keto reductase family 1 member A1

BE0004352ProteinHumansAKR1A1

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:10510318, PubMed:30538128). It is acted on by 11 drugs in DrugBank.

Gene name
AKR1A1
UniProtKB entry
P14550Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
325 residues · 36,573 Da
Also known as
1.1.1.2 · 1.1.1.372 · 1.1.1.54 · Alcohol dehydrogenase [NADP(+)] · Aldehyde reductase

Resolves to

Protein
UniProtP14550UniProt nameAK1A1_HUMAN
Gene
HGNCHGNC:380NCBI Gene10327GenBank178481GeneCardsAKR1A1
Pharmacology
KEGGhsa:10327
Structure
PDB2ALR
Drugs

What you can answer from here — as of September 03, 2024

11DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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9Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldo-keto reductase family 1 member A1, how selective are they, and which programs against it are still in active trials?

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