Aldehyde dehydrogenase, mitochondrial

BE0000133ProteinHumansALDH2

Mitochondrial aldehyde dehydrogenase with broad substrate specificity which participates in the detoxification of ethanol-derived acetaldehyde and endogenous aldehydes, including those arising from lipid peroxidation (PubMed:16956664, PubMed:22339434, PubMed:33355142, PubMed:39075523). It is acted on by 19 drugs in DrugBank.

Gene name
ALDH2
UniProtKB entry
P05091Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
517 residues · 56,381 Da
Also known as
1.2.1.19 · 1.2.1.24 · 1.2.1.3 · 1.2.1.36 · 1.2.1.46

Resolves to

Protein
UniProtP05091UniProt nameALDH2_HUMAN
Gene
HGNCHGNC:404NCBI Gene217GenBank28606GeneCardsALDH2
Pharmacology
IUPHAR/GtoPdb2595KEGGhsa:217
Structure
PDB1CW3PDB1NZWPDB1NZX
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7Metabolic reactionsDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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57+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldehyde dehydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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