Reaction: Linezolid to 1 product

Reaction
Linezolid
DB00601
    PNU-142300
    DBMET03355
    Reaction type
    oxidation; ring opening
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    inactive
    References
    1. Slatter JG, Stalker DJ, Feenstra KL, Welshman IR, Bruss JB, Sams JP, Johnson MG, Sanders PE, Hauer MJ, Fagerness PE, Stryd RP, Peng GW, Shobe EM: Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [(14)C]linezolid to healthy human subjects. Drug Metab Dispos. 2001 Aug;29(8):1136-45. [Article]
    2. FDA Approved Drug Products: Zyvox (linezolid) for intravenous or oral administration [Link]
    3. FDA Pharmacology and Biopharmaceutics Review: Linezolid [Link]
    Comments
    Reaction is presumed enzymatic, but the specific enzymes responsible have not been elucidated.
    Enzymes
    Not Available