Reaction: Macitentan to 1 product

Reaction
Macitentan
DB08932
M4 (Macitentan)
DBMET03424
Reaction type
oxidation
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Sidharta PN, Treiber A, Dingemanse J: Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan. Clin Pharmacokinet. 2015 May;54(5):457-71. doi: 10.1007/s40262-015-0255-5. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C9Not AvailableNot Availableconfirmed