Reaction: Roxadustat to 1 product

Reaction
Reaction type
O-glucuronidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Hansson A, Thevis M, Cox H, Miller G, Eichner D, Bondesson U, Hedeland M: Investigation of the metabolites of the HIF stabilizer FG-4592 (roxadustat) in five different in vitro models and in a human doping control sample using high resolution mass spectrometry. J Pharm Biomed Anal. 2017 Feb 5;134:228-236. doi: 10.1016/j.jpba.2016.11.041. Epub 2016 Nov 27. [Article]
  2. EMA Approved Drug Products: Evrenzo (roxadustat) oral tablets [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C8Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 1-9Not AvailableNot Availableimplied