Cytochrome P450 2C8

BE0002887ProteinHumansCYP2C8

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). It is acted on by 354 drugs in DrugBank.

Gene name
CYP2C8
UniProtKB entry
P10632Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
490 residues · 55,824 Da
Also known as
1.14.14.1 · CYPIIC8 · Cytochrome P450 form 1 · Cytochrome P450 IIC2 · Cytochrome P450 MP-12

Resolves to

Protein
UniProtP10632UniProt nameCP2C8_HUMAN
Gene
HGNCHGNC:2622NCBI Gene1558GeneCardsCYP2C8
Pharmacology
IUPHAR/GtoPdb1325KEGGhsa:1558
Structure
PDB1PQ2PDB2NNHPDB2NNI
Drugs

What you can answer from here — as of September 07, 2019

354DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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165Metabolic reactionsDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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653+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 2C8, how selective are they, and which programs against it are still in active trials?

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