Reaction: S-4'-hydroxybupropion to 1 product
ketoreductionMetabolism of Bupropion
S-4'-hydroxybupropion is converted to R,S-erythro-4'-hydroxy-hydrobupropion by 11-beta-hydroxysteroid dehydrogenase 1 and Aldo-keto reductase family 7 member A3.
- Reaction
- Direction
- Comments
- Aflatoxin B1 aldehyde reductase member 3 (AKR7) is the main enzyme that catalyzes the reaction in the intestine, while corticosteroid 11-beta dehydrogenase (HSD11B1) is the main enzyme responsible in the liver.[A247010]
What you can answer from here — as of April 29, 2022
2EnzymesEach linked to its target cardListed above
Which other drugs are metabolised by 11-beta-hydroxysteroid dehydrogenase 1 and Aldo-keto reductase family 7 member A3, and which of those pairings are clinically significant?
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