Reaction: Sulfasalazine to 2 products

Reaction
Sulfasalazine
DB00795
    Mesalazine
    DB00244
    Sulfapyridine
    DB00891
    Reaction type
    reductive cleavage
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    active
    References
    1. Klotz U: Clinical pharmacokinetics of sulphasalazine, its metabolites and other prodrugs of 5-aminosalicylic acid. Clin Pharmacokinet. 1985 Jul-Aug;10(4):285-302. doi: 10.2165/00003088-198510040-00001. [Article]
    Comments
    The reaction was catalyzed by azoreductase enzyme by colonic bacteria.[A255136]
    Enzymes
    Not Available