Reaction: Ketotifen to 1 product
- Reaction
- Reaction type
- N-glucuronidation
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- unknown
- References
- Hawes EM: N+-glucuronidation, a common pathway in human metabolism of drugs with a tertiary amine group. Drug Metab Dispos. 1998 Sep;26(9):830-7. [Article]
- Kato Y, Izukawa T, Oda S, Fukami T, Finel M, Yokoi T, Nakajima M: Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4. Drug Metab Dispos. 2013 Jul;41(7):1389-97. doi: 10.1124/dmd.113.051565. Epub 2013 Apr 23. [Article]
- Health Canada Product Monograph: Zaditen (ketotifen fumarate) for oral administration [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role UDP-glucuronosyltransferase 1A3 Not Available Not Available confirmed UDP-glucuronosyltransferase 1A4 Not Available Not Available confirmed UDP-glucuronosyltransferase 2B10 Not Available Not Available confirmed