UDP-glucuronosyltransferase 1A4

BE0003544ProteinHumansUGT1A4

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623, PubMed:15231852). It is acted on by 42 drugs in DrugBank.

Gene name
UGT1A4
UniProtKB entry
P22310Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
534 residues · 60,025 Da
Also known as
2.4.1.17 · Bilirubin-specific UDPGT isozyme 2 · GNT1 · hUG-BR2 · UDP-glucuronosyltransferase 1-4

Resolves to

Protein
UniProtP22310UniProt nameUD14_HUMAN
Gene
HGNCHGNC:12536NCBI Gene54657GenBank184475GeneCardsUGT1A4
Pharmacology
KEGGhsa:54657
Drugs

What you can answer from here — as of September 03, 2024

42DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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19Metabolic reactionsDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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67+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 1A4, how selective are they, and which programs against it are still in active trials?

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