UDP-glucuronosyltransferase 1A3

BE0003677ProteinHumansUGT1A3

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240,... It is acted on by 61 drugs in DrugBank.

Gene name
UGT1A3
UniProtKB entry
P35503Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
534 residues · 60,338 Da
Also known as
2.4.1.17 · GNT1 · UDP-glucuronosyltransferase 1-3 · UDP-glucuronosyltransferase 1-C · UDP-glucuronosyltransferase 1A isoform 3

Resolves to

Protein
UniProtP35503UniProt nameUD13_HUMAN
Gene
HGNCHGNC:12535NCBI Gene54659GenBank340135GeneCardsUGT1A3
Pharmacology
KEGGhsa:54659
Drugs

What you can answer from here — as of September 03, 2024

61DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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46Metabolic reactionsDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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80+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 1A3, how selective are they, and which programs against it are still in active trials?

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