Reaction: Pilocarpine to 2 products

Reaction
Pilocarpine
DB01085
3-Hydroxyisopilocarpine
DBMET03744
3-Hydroxypilocarpine
DBMET03743
Reaction type
3-hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Endo T, Ban M, Hirata K, Yamamoto A, Hara Y, Momose Y: Involvement of CYP2A6 in the formation of a novel metabolite, 3-hydroxypilocarpine, from pilocarpine in human liver microsomes. Drug Metab Dispos. 2007 Mar;35(3):476-83. doi: 10.1124/dmd.106.013425. Epub 2006 Dec 18. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2A6Not AvailableNot Availableimplied