Cytochrome P450 2A6

BE0003336ProteinHumansCYP2A6

Exhibits a high coumarin 7-hydroxylase activity. It is acted on by 102 drugs in DrugBank.

Gene name
CYP2A6
UniProtKB entry
P11509Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
494 residues · 56,517 Da
Also known as
1,4-cineole 2-exo-monooxygenase · 1.14.14.- · Coumarin 7-hydroxylase · CYP2A3 · CYPIIA6

Resolves to

Protein
UniProtP11509UniProt nameCP2A6_HUMAN
Gene
HGNCHGNC:2610NCBI Gene1548GeneCardsCYP2A6
Pharmacology
IUPHAR/GtoPdb1321KEGGhsa:1548
Structure
PDB1Z10PDB1Z11PDB2FDU
Drugs

What you can answer from here — as of September 07, 2019

102DrugsApproved to experimental, with action, bond type and pharmacological action
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55Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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217+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 2A6, how selective are they, and which programs against it are still in active trials?

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