Reaction: Pilocarpine to 1 product

Reaction
Pilocarpine
DB01085
Pilocarpic acid
DBMET03745
Reaction type
hydrolysis
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Hioki T, Fukami T, Nakajima M, Yokoi T: Human paraoxonase 1 is the enzyme responsible for pilocarpine hydrolysis. Drug Metab Dispos. 2011 Aug;39(8):1345-52. doi: 10.1124/dmd.111.038141. Epub 2011 Apr 26. [Article]
  2. Endo T, Ban M, Hirata K, Yamamoto A, Hara Y, Momose Y: Involvement of CYP2A6 in the formation of a novel metabolite, 3-hydroxypilocarpine, from pilocarpine in human liver microsomes. Drug Metab Dispos. 2007 Mar;35(3):476-83. doi: 10.1124/dmd.106.013425. Epub 2006 Dec 18. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Serum paraoxonase/arylesterase 1Not AvailableNot Availableimplied