Serum paraoxonase/arylesterase 1

BE0000930ProteinHumansPON1

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. It is acted on by 14 drugs in DrugBank.

Gene name
PON1
UniProtKB entry
P27169Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
355 residues · 39,731 Da
Also known as
3.1.1.2 · 3.1.1.81 · 3.1.8.1 · A-esterase 1 · Aromatic esterase 1

Resolves to

Protein
UniProtP27169UniProt namePON1_HUMAN
Gene
HGNCHGNC:9204NCBI Gene5444GenBank190192GeneCardsPON1
Pharmacology
KEGGhsa:5444
Structure
PDB1V04
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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4Metabolic reactionsDrug transformations it catalyses, substrate to product
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serum paraoxonase/arylesterase 1, how selective are they, and which programs against it are still in active trials?

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