Reaction: Sofpironium to 1 product
- Reaction
- Reaction type
- esterase hydrolysis
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- inactive
- References
- Samir A, Ohura K, Bodor N, Imai T: Identification of Major Esterase Involved in Hydrolysis of Soft Anticholinergic (2R3'R-SGM) Designed From Glycopyrrolate in Human and Rat Tissues. J Pharm Sci. 2019 Aug;108(8):2791-2797. doi: 10.1016/j.xphs.2019.03.030. Epub 2019 Apr 5. [Article]
- FDA Approved Drug Products: Sofdra (sofpironium bromide) topical gel [Link]
- 2021 Fall Clinical Dermatology Conference: Investigating Treatment of Primary Axillary Hyperhidrosis With a Topical Retrometabolic Anticholinergic Drug [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Serum paraoxonase/arylesterase 1 Not Available Not Available confirmed