Morphine sulfateProduct ingredient for Morphine
- Name
- Morphine sulfate
- Drug Entry
- Morphine
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.1 It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse.2 Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.13
- Accession Number
- DBSALT000122
- Structure
Structure for Morphine sulfate (DBSALT000122)
- Synonyms
- Morphine sulfate concentrate (preservative free) / Morphine sulfate, anhydrous / Morphine sulphate / Morphine sulphate anhydrous
- UNII
- DY70C97N30
- CAS Number
- 64-31-3
- Weight
- Average: 668.754
Monoisotopic: 668.2403662 - Chemical Formula
- C34H40N2O10S
- InChI Key
- USAHOPJHPJHUNS-IFCNUISUSA-N
- InChI
- InChI=1S/2C17H19NO3.H2O4S/c2*1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2*2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t2*10-,11+,13-,16-,17-;/m00./s1
- IUPAC Name
- bis((1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15-tetraene-10,14-diol); sulfuric acid
- SMILES
- OS(O)(=O)=O.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@]2([H])O.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@]2([H])O
- External Links
- PubChem Compound
- 5462349
- ChemSpider
- 4575388
- ChEBI
- 7003
- ChEMBL
- CHEMBL2096625
- Wikipedia
- Morphine
- Predicted Properties
Property Value Source Water Solubility 10.2 mg/mL ALOGPS logP 0.99 ALOGPS logP 0.9 Chemaxon logS -1.4 ALOGPS pKa (Strongest Acidic) 10.26 Chemaxon pKa (Strongest Basic) 9.12 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 52.93 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 80.12 m3·mol-1 Chemaxon Polarizability 30.01 Å3 Chemaxon Number of Rings 10 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon