Buspirone hydrochlorideProduct ingredient for Buspirone

Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class,² buspirone is a serotonin 5-HT_1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs.¹³ Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, buspirone been termed 'anxioselective'.¹ First synthesized in 1968 then patented in 1975,¹⁰ it is commonly marketed under the brand name Buspar®. Buspirone was first approved in 1986 by the FDA ⁴ and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate.¹⁰ The potential use of buspirone in combination with melatonin in depression and cognitive impairment via promoting neurogenesis has also been investigated.⁴

PubChem Compound

36431

ChemSpider

33481

ChEBI

3224

ChEMBL

CHEMBL1200399

Wikipedia

Buspirone