Amiodarone hydrochlorideProduct ingredient for Amiodarone
- Name
- Amiodarone hydrochloride
- Drug Entry
- Amiodarone
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings.4 Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved for its approved indications, according to prescribing information.18,19,20
- Accession Number
- DBSALT000355
- Structure
Structure for Amiodarone hydrochloride (DBSALT000355)
- Synonyms
- Amiodarone HCl
- UNII
- 976728SY6Z
- CAS Number
- 19774-82-4
- Weight
- Average: 681.773
Monoisotopic: 681.000358378 - Chemical Formula
- C25H30ClI2NO3
- InChI Key
- ITPDYQOUSLNIHG-UHFFFAOYSA-N
- InChI
- InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
- IUPAC Name
- {2-[4-(2-butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]ethyl}diethylamine hydrochloride
- SMILES
- Cl.CCCCC1=C(C(=O)C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)C2=CC=CC=C2O1
- External Links
- KEGG Drug
- D00636
- PubChem Compound
- 29770
- ChemSpider
- 27664
- ChEBI
- 2664
- ChEMBL
- CHEMBL1083993
- Wikipedia
- Amiodarone
- Predicted Properties
Property Value Source Water Solubility 0.00476 mg/mL ALOGPS logP 7.24 ALOGPS logP 7.64 Chemaxon logS -5.1 ALOGPS pKa (Strongest Basic) 9.08 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 42.68 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 145.05 m3·mol-1 Chemaxon Polarizability 57.36 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon