Flunarizine dihydrochlorideProduct ingredient for Flunarizine
- Name
- Flunarizine dihydrochloride
- Drug Entry
- Flunarizine
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
- Accession Number
- DBSALT000382
- Structure
Structure for Flunarizine dihydrochloride (DBSALT000382)
- Synonyms
- Flunarizine diHCl / flunarizine hydrochloride
- UNII
- C11102TO53
- CAS Number
- 30484-77-6
- Weight
- Average: 477.417
Monoisotopic: 476.15976073 - Chemical Formula
- C26H28Cl2F2N2
- InChI Key
- RXKMOPXNWTYEHI-RDRKJGRWSA-N
- InChI
- InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
- IUPAC Name
- 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine dihydrochloride
- SMILES
- Cl.Cl.[H]\C(CN1CCN(CC1)C(C1=CC=C(F)C=C1)C1=CC=C(F)C=C1)=C(\[H])C1=CC=CC=C1
- External Links
- PubChem Compound
- 5282407
- ChemSpider
- 4445562
- ChEBI
- 31621
- ChEMBL
- CHEMBL552659
- Predicted Properties
Property Value Source Water Solubility 0.00168 mg/mL ALOGPS logP 5.3 ALOGPS logP 6.17 Chemaxon logS -5.4 ALOGPS pKa (Strongest Basic) 7.22 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.48 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 120.3 m3·mol-1 Chemaxon Polarizability 43.79 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon