Promethazine hydrochlorideProduct ingredient for Promethazine
- Name
- Promethazine hydrochloride
- Drug Entry
- Promethazine
Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of phenothiazine that was developed in France in 1946.1 Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.2,8,9,7,10
Promethazine was granted FDA approval before 29 March 1951.11,12
- Accession Number
- DBSALT000427
- Structure
Structure for Promethazine hydrochloride (DBSALT000427)
- Synonyms
- Promethazine HCl
- UNII
- R61ZEH7I1I
- CAS Number
- 58-33-3
- Weight
- Average: 320.88
Monoisotopic: 320.111397079 - Chemical Formula
- C17H21ClN2S
- InChI Key
- XXPDBLUZJRXNNZ-UHFFFAOYSA-N
- InChI
- InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
- IUPAC Name
- dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine hydrochloride
- SMILES
- Cl.CC(CN1C2=CC=CC=C2SC2=CC=CC=C12)N(C)C
- External Links
- PubChem Compound
- 6014
- ChemSpider
- 5792
- ChEBI
- 8462
- ChEMBL
- CHEMBL1200750
- Wikipedia
- Promethazine
- Predicted Properties
Property Value Source Water Solubility 0.0245 mg/mL ALOGPS logP 4.52 ALOGPS logP 4.29 Chemaxon logS -4.1 ALOGPS pKa (Strongest Basic) 9.05 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.48 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 88.5 m3·mol-1 Chemaxon Polarizability 31.9 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon