Quinapril HydrochlorideProduct ingredient for Quinapril
- Name
- Quinapril Hydrochloride
- Drug Entry
- Quinapril
Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.6,7 It is used to treat hypertension and heart failure.6,7 ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.5
Quinapril was granted FDA approval on 19 November 1991.6 A combination tablet with hydrochlorothiazide was also approved on 28 December 1999.7
- Accession Number
- DBSALT000465
- Structure
Structure for Quinapril Hydrochloride (DBSALT000465)
- Synonyms
- Quinapril HCl
- External IDs
- CI 906 / CI-906
- UNII
- 33067B3N2M
- CAS Number
- 82586-55-8
- Weight
- Average: 474.977
Monoisotopic: 474.192149819 - Chemical Formula
- C25H31ClN2O5
- InChI Key
- IBBLRJGOOANPTQ-JKVLGAQCSA-N
- InChI
- InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1
- IUPAC Name
- (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
- SMILES
- Cl.[H][C@@](C)(N[C@@]([H])(CCC1=CC=CC=C1)C(=O)OCC)C(=O)N1CC2=CC=CC=C2C[C@@]1([H])C(O)=O
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.0085 mg/mL ALOGPS logP 1.4 ALOGPS logP 1.96 Chemaxon logS -4.7 ALOGPS pKa (Strongest Acidic) 3.7 Chemaxon pKa (Strongest Basic) 5.2 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 95.94 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 119.96 m3·mol-1 Chemaxon Polarizability 47.33 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon