Cevimeline hydrochlorideProduct ingredient for Cevimeline
- Name
- Cevimeline hydrochloride
- Drug Entry
- Cevimeline
Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
- Accession Number
- DBSALT000805
- Structure
Structure for Cevimeline hydrochloride (DBSALT000805)
- Synonyms
- Cevimeline HCl
- External IDs
- AF102B / FKS-508 / SND-5008 / SNI-2011 / SNK-508
- UNII
- P81Q6V85NP
- CAS Number
- 153504-70-2
- Weight
- Average: 489.56
Monoisotopic: 488.1700908 - Chemical Formula
- C20H38Cl2N2O3S2
- InChI Key
- ZSTLCHCDLIUXJE-ZGBAEQJLSA-N
- InChI
- InChI=1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m00.../s1
- IUPAC Name
- bis((2S,5'S)-5'-methyl-4-azaspiro[bicyclo[2.2.2]octane-2,2'-[1,4]oxathiolane]) hydrate dihydrochloride
- SMILES
- O.Cl.Cl.[H][C@]1(C)O[C@]2(CS1)CN1CCC2CC1.[H][C@]1(C)O[C@]2(CS1)CN1CCC2CC1
- External Links
- Human Metabolome Database
- HMDB0061079
- PubChem Compound
- 83898
- ChemSpider
- 32700696
- ChEBI
- 775218
- PharmGKB
- PA164754754
- Wikipedia
- Cevimeline
- Predicted Properties
Property Value Source Water Solubility 2.41 mg/mL ALOGPS logP 1.46 ALOGPS logP 1 Chemaxon logS -1.9 ALOGPS pKa (Strongest Basic) 8.59 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 12.47 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 55.92 m3·mol-1 Chemaxon Polarizability 21.85 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon