Dorzolamide hydrochlorideProduct ingredient for Dorzolamide

Dorzolamide is a non-bacteriostatic sulfonamide derivative ² and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular hypertension.⁶ It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes.¹ Unlike oral CA inhibitors, dorzolamide has negligible effects of acid-base or electrolyte disturbances and other systemic adverse effects.² First marketed in 1995,⁵ dorzolamide is available in ophthalmic solutions as monotherapy marketed as Trusopt ⁶ or in combination with timolol as Cosopt PF.⁷