Clodronate disodiumProduct ingredient for Clodronic acid

Clodronic acid is a first generation bisphosphonate similar to etidronic acid and tiludronic acid.¹ These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.² clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid.¹

Clodronic acid is not FDA approved, but is approved in Canada.⁸