Avibactam sodiumProduct ingredient for Avibactam
- Name
- Avibactam sodium
- Drug Entry
- Avibactam
Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant gram-negative bacterial pathogens. As there is limited clinical safety and efficacy data, Avycaz should be reserved for patients over 18 years old who have limited or not alternative treatment options.
- Accession Number
- DBSALT001486
- Structure
Structure for Avibactam sodium (DBSALT001486)
- Synonyms
- Not Available
- UNII
- 9V824P8TAI
- CAS Number
- 1192491-61-4
- Weight
- Average: 287.22
Monoisotopic: 287.01880051 - Chemical Formula
- C7H10N3NaO6S
- InChI Key
- RTCIKUMODPANKX-JBUOLDKXSA-M
- InChI
- InChI=1S/C7H11N3O6S.Na/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15;/h4-5H,1-3H2,(H2,8,11)(H,13,14,15);/q;+1/p-1/t4-,5+;/m1./s1
- IUPAC Name
- sodium (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
- SMILES
- [Na+].NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS([O-])(=O)=O
- External Links
- KEGG Drug
- D10340
- ChemSpider
- 9675010
- BindingDB
- 159600
- ChEBI
- 85982
- ChEMBL
- CHEMBL2107817
- Predicted Properties
Property Value Source Water Solubility 18.7 mg/mL ALOGPS logP -0.56 ALOGPS logP -3.6 Chemaxon logS -1.2 ALOGPS pKa (Strongest Acidic) -2 Chemaxon pKa (Strongest Basic) -3.9 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 133.07 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 51.36 m3·mol-1 Chemaxon Polarizability 21.85 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon