Masitinib mesylateProduct ingredient for Masitinib
- Name
- Masitinib mesylate
- Drug Entry
- Masitinib
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the USA it is distributed under the name Kinavet and has been available for veterinaries since 2011.
- Accession Number
- DBSALT001689
- Structure
Structure for Masitinib mesylate (DBSALT001689)
- Synonyms
- Masitinib mesilate
- UNII
- ZK89EG3A18
- CAS Number
- 1048007-93-7
- Weight
- Average: 594.75
Monoisotopic: 594.208295947 - Chemical Formula
- C29H34N6O4S2
- InChI Key
- TXCWBWKVIZGWEQ-UHFFFAOYSA-N
- InChI
- InChI=1S/C28H30N6OS.CH4O3S/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34;1-5(2,3)4/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32);1H3,(H,2,3,4)
- IUPAC Name
- N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide; methanesulfonic acid
- SMILES
- CS(O)(=O)=O.CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC=C(C)C(NC3=NC(=CS3)C3=CN=CC=C3)=C2)CC1
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.00289 mg/mL ALOGPS logP 4.18 ALOGPS logP 4.97 Chemaxon logS -5.2 ALOGPS pKa (Strongest Acidic) 15.12 Chemaxon pKa (Strongest Basic) 7.84 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 73.39 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 147 m3·mol-1 Chemaxon Polarizability 55.33 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon