Avatrombopag maleateProduct ingredient for Avatrombopag
- Name
- Avatrombopag maleate
- Drug Entry
- Avatrombopag
Avatrombopag (Doptelet), is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation 3, 10. This decreases the need for blood transfusions 10.
Patients with thrombocytopenia and chronic liver disease (leading to thrombocytopenia) often require platelet transfusions before surgical procedures to decrease the risk of bleeding 1. Thrombocytopenia (or decreased numbers of platelets) is a common complication in patients suffering from chronic liver disease, either as an immediate result of liver disease or a consequence of interferon-based antiviral therapy 16.
Avatrombopag was approved by the FDA on May 21, 2018 for thrombocytopenia (low platelets) in adults with chronic liver disease who are scheduled to undergo a procedure 14. It is administered orally as avatrombopag maleate, its salt form 11.
Doptelet (Avatrombopag) is the first orally administered treatment option for patients with chronic liver disease, allowing a large population of patients to avoid a platelet transfusion before a procedure by increasing platelet counts to the optimal level of greater or equal to 50,000 per microliter 15.
- Accession Number
- DBSALT002118
- Structure
Structure for Avatrombopag maleate (DBSALT002118)
- Synonyms
- Not Available
- UNII
- GDW7M2P1IS
- CAS Number
- 677007-74-8
- Weight
- Average: 765.72
Monoisotopic: 764.1620453 - Chemical Formula
- C33H38Cl2N6O7S2
- InChI Key
- MISPBGHDNZYFNM-BTJKTKAUSA-N
- InChI
- InChI=1S/C29H34Cl2N6O3S2.C4H4O4/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40;5-3(6)1-2-4(7)8/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38);1-2H,(H,5,6)(H,7,8)/b;2-1-
- IUPAC Name
- (2Z)-but-2-enedioic acid; 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid
- SMILES
- OC(=O)\C=C/C(O)=O.OC(=O)C1CCN(CC1)C1=C(Cl)C=C(C=N1)C(=O)NC1=NC(C2=CC(Cl)=CS2)=C(S1)N1CCN(CC1)C1CCCCC1
- External Links
- ChemSpider
- 8094226
- ChEMBL
- CHEMBL2105758
- PharmGKB
- PA166179849
- Predicted Properties
Property Value Source Water Solubility 0.00465 mg/mL ALOGPS logP 5.97 ALOGPS logP 4.17 Chemaxon logS -5.2 ALOGPS pKa (Strongest Acidic) 3.5 Chemaxon pKa (Strongest Basic) 8.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 101.9 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 169.16 m3·mol-1 Chemaxon Polarizability 69.92 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon