Terlipressin acetateProduct ingredient for Terlipressin

Terlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor.¹ It is a prodrug of lypressin, or lysine vasopressin. Compared to endogenous vasopressin, terlipressin has a longer half life and increased selectivity for the V1 receptor.⁸ As a potent vasopressor, terlipressin has been investigated in various shock states and conditions with diminished vasomotor tone.^1,2,3,4,5 It was also studied in hepatorenal syndrome (HRS) and variceal bleeding.⁶ The drug was first approved by the FDA in September 2022.⁸