Sodium iodide I-131Product ingredient for Iodide I-131
- Name
- Sodium iodide I-131
- Drug Entry
- Iodide I-131
Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation dose is via gamma radiation, while the other 90% (beta radiation) causes tissue damage without contributing to any ability to see or image the isotope. Low levels of beta radiation are also known for causing cancer as this dose is highly mutagenic. For this reason, less toxic iodine isotopes such as I-123 are more frequently used in nuclear imaging, while I-131 is reserved for its tissue destroying effects. Because the thyroid gland naturally takes up iodine from the body, therapeutic methods using radioisotopes can take advantage of this mechanism for localization of drug to the site of malignancy.
Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid carcinomas that take up iodine. Palliative effects may be observed in patients with advanced thyroid malignancy if the metastatic lesions take up iodine. It is also indicated for use in performance of the radioactive iodide (RAI) uptake test to evaluate thyroid function.
- Accession Number
- DBSALT002460
- Structure
- Synonyms
- Iodine (131I) sodium / Sodio ioduro (131I) / Sodium iodide (131 I) / Sodium iodide (131I) / Sodium iodide I 131 / Sodium iodide I131 / Sodium iodide-131 / Sodium iodide, I-131 / Sodium iodide,I-131
- UNII
- 29VCO8ACHH
- CAS Number
- 7790-26-3
- Weight
- Average: 153.8959
Monoisotopic: 153.89589345 - Chemical Formula
- INa
- InChI Key
- FVAUCKIRQBBSSJ-LAIFMVDKSA-M
- InChI
- InChI=1S/HI.Na/h1H;/q;+1/p-1/i1+4;
- IUPAC Name
- (¹³¹I)iodosodium
- SMILES
- [Na][131I]
- External Links
- ChemSpider
- 64464
- ChEMBL
- CHEMBL1201084
- Predicted Properties
Property Value Source logP -0.57 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 13.34 m3·mol-1 Chemaxon Polarizability 6.98 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon