Alaproclate hydrochlorideProduct ingredient for Alaproclate
- Name
- Alaproclate hydrochloride
- Drug Entry
- Alaproclate
Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity observed in animal studies. Alaproclate has also been found to act as a non-competitive NMDA receptor antagonist although without discriminative stimulus properties similar to phencyclidine.
- Accession Number
- DBSALT002575
- Structure
Structure for Alaproclate hydrochloride (DBSALT002575)
- Synonyms
- Not Available
- UNII
- NIH506S9US
- CAS Number
- 60719-83-7
- Weight
- Average: 292.2
Monoisotopic: 291.0792843 - Chemical Formula
- C13H19Cl2NO2
- InChI Key
- OPAKSOWFKIUFNP-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H18ClNO2.ClH/c1-9(15)12(16)17-13(2,3)8-10-4-6-11(14)7-5-10;/h4-7,9H,8,15H2,1-3H3;1H
- IUPAC Name
- 1-(4-chlorophenyl)-2-methylpropan-2-yl 2-aminopropanoate hydrochloride
- SMILES
- Cl.CC(N)C(=O)OC(C)(C)CC1=CC=C(Cl)C=C1
- External Links
- ChemSpider
- 10131704
- ChEMBL
- CHEMBL1256359
- Predicted Properties
Property Value Source Water Solubility 0.0377 mg/mL ALOGPS logP 2.82 ALOGPS logP 2.88 Chemaxon logS -3.8 ALOGPS pKa (Strongest Basic) 7.34 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 52.32 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 68.5 m3·mol-1 Chemaxon Polarizability 27.04 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon