Brilaroxazine hydrochlorideProduct ingredient for Brilaroxazine
- Name
- Brilaroxazine hydrochloride
- Drug Entry
- Brilaroxazine
Brilaroxazine (RP5063) is an investigational atypical antipsychotic which is under development by Reviva Pharmaceuticals for the treatment of schizophrenia and schizoaffective disorder. Reviva Pharmaceuticals also intends to investigate RP5063 for the treatment of bipolar disorder, major depressive disorder, psychosis/agitation associated with Alzheimer's disease, Parkinson's disease psychosis, attention deficit hyperactivity disorder (ADD/ADHD), and autism. As of May 2015, it is in phase III clinical trials for schizophrenia.
- Accession Number
- DBSALT002782
- Structure
Structure for Brilaroxazine hydrochloride (DBSALT002782)
- Synonyms
- 6-(4-(4-(2,3-Dichlorophenyl)-piperazin-1-yl)-butoxy)-2H-benzo(b)(1,4)oxazin-3(4H)-one hydrochloride / 6-(4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride / 6-(4-(4-(2,3-Dicholorophenyl) piperazin-1-yl) butoxy)-2H-benzo [b] [1,4] oxazin-3(4H)-one hydrochloride / Brilaroxazine HCl
- UNII
- I440YY0HX0
- CAS Number
- 1708960-04-6
- Weight
- Average: 486.82
Monoisotopic: 485.1039748 - Chemical Formula
- C22H26Cl3N3O3
- InChI Key
- GMTQOJSRMVAFIF-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H25Cl2N3O3.ClH/c23-17-4-3-5-19(22(17)24)27-11-9-26(10-12-27)8-1-2-13-29-16-6-7-20-18(14-16)25-21(28)15-30-20;/h3-7,14H,1-2,8-13,15H2,(H,25,28);1H
- IUPAC Name
- 6-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride
- SMILES
- Cl.ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCOC2=CC=C3OCC(=O)NC3=C2)CC1
- External Links
- ChemSpider
- 64853710
- Predicted Properties
Property Value Source Water Solubility 0.0339 mg/mL ALOGPS logP 5.06 ALOGPS logP 4.14 Chemaxon logS -4.1 ALOGPS pKa (Strongest Acidic) 11.42 Chemaxon pKa (Strongest Basic) 7.47 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 54.04 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 120.98 m3·mol-1 Chemaxon Polarizability 47.59 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon