Zinc gluconate trihydrateProduct ingredient for Zinc gluconate

Name
Zinc gluconate trihydrate
Drug Entry
Zinc gluconate

Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA 9. It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and with decreased symptom severity.

Although it has been nasally administered for treating the common cold, this route of administration has been associated with some cases of anosmia 5, 1, 2, 7.

Studies show that zinc may be better absorbed in humans in the gluconate form 4, 19, however, results from other studies may vary.6,10

Interestingly, zinc supplementation has become a critical intervention for treating diarrheal episodes in children. Studies suggest that administration of zinc along with new low osmolarity oral rehydration solutions/salts (oral rehydration solution), may reduce both the duration and severity of diarrheal episodes for up to 12 weeks 8.

More information about Zinc (in its natural form) is available at Zinc.

Accession Number
DBSALT002891
Structure
Synonyms
Not Available
UNII
F2F0XU34WQ
CAS Number
12389-19-4
Weight
Average: 509.72
Monoisotopic: 508.061791
Chemical Formula
C12H28O17Zn
InChI Key
ZPQPBMFYUZNVPE-BMDZSJGYSA-L
InChI
InChI=1S/2C6H12O7.3H2O.Zn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;/h2*2-5,7-11H,1H2,(H,12,13);3*1H2;/q;;;;;+2/p-2/t2*2-,3-,4+,5-;;;;/m11..../s1
IUPAC Name
zinc(2+) bis(2,3,4,5,6-pentahydroxyhexanoate) trihydrate
SMILES
O.O.O.[Zn++].[H]C(O)(CO)C([H])(O)C([H])(O)C([H])(O)C([O-])=O.[H]C(O)(CO)C([H])(O)C([H])(O)C([H])(O)C([O-])=O
ChemSpider
32699535
Predicted Properties
PropertyValueSource
Water Solubility40.0 mg/mLALOGPS
logP-2ALOGPS
logP-3.4Chemaxon
logS-1.1ALOGPS
pKa (Strongest Acidic)3.39Chemaxon
pKa (Strongest Basic)-3Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count5Chemaxon
Polar Surface Area141.28 Å2Chemaxon
Rotatable Bond Count10Chemaxon
Refractivity49.11 m3·mol-1Chemaxon
Polarizability16.55 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon