Magnesium ValproateProduct ingredient for Valproic acid
- Name
- Magnesium Valproate
- Drug Entry
- Valproic acid
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton.26 It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects of khelline when he found that all of his samples, dissolved in valproic acid, exerted a similar degree of anticonvulsive activity. It first received approval on February 28, 1978 from the FDA under the trade name Depakene.29
Since then, it has been investigated for neuroprotective, anti-manic, and anti-migraine effects. It is currently a compound of interest in the field of oncology for its anti-proliferative effects and is the subject of many clinical trials in a variety of cancer types.
- Accession Number
- DBSALT003326
- Structure
Structure for Magnesium Valproate (DBSALT003326)
- Synonyms
- Not Available
- UNII
- Q400352CM2
- CAS Number
- 62959-43-7
- Weight
- Average: 453.924
Monoisotopic: 453.30720445 - Chemical Formula
- C24H45MgO6
- InChI Key
- LKLLHOIUJVEAGU-UHFFFAOYSA-L
- InChI
- InChI=1S/2C8H16O2.Mg/c2*1-3-5-7(6-4-2)8(9)10;/h2*7H,3-6H2,1-2H3,(H,9,10);/q;;+2/p-2
- IUPAC Name
- SMILES
- [Mg++].CCCC(CCC)C([O-])=O.CCCC(CCC)C([O-])=O
- External Links
- ChemSpider
- 130084
- ChEMBL
- CHEMBL2315212
- Predicted Properties
Property Value Source Water Solubility 0.00716 mg/mL ALOGPS logP 5.82 ALOGPS logS -4.6 ALOGPS Ghose Filter No Chemaxon