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Urokinase
go.drugbank.com/drugs/DB00013ApprovedInvestigationalWithdrawnUrokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. … [A191943] Urokinase remains connected between these 2 chains by a sulfhydryl bond.[A191943] Urokinase was granted FDA approval on 16 January 1978.[L12138]
Products: UROKINASE KGCC INJ. 250000 IU FLAKON, 1 ADET, UROKINASE KGCC INJ. 500000 IU FLAKON, 1 ADETMepolizumab
go.drugbank.com/drugs/DB06612ApprovedInvestigationalThe pathogenesis of eosinophilia is complex, but IL-5 is recognized as a key cytokine involved in the differentiation, recruitment, activation, and prolonged survival of eosinophils in peripheral tissue … Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm<sup>3</sup> or more) is associated with a spectrum
Categories: Interleukin-5 AntagonistProducts: NUCALA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML, NUCALA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 100MG/MLInterferon alfa-2b
go.drugbank.com/drugs/DB00105ApprovedInvestigationalInterferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. … This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
Mixtures: Rebetron Ready To Use Solution (albumin(human)free) (6000000 Iu/ml and 200mg Capsules), Intron ACategories: Interferon Type I, Cytochrome P-450 CYP1A2 InhibitorsAntithrombin III human
go.drugbank.com/drugs/DB11598ApprovedInvestigationalA plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Synonyms: Antithrombin III (human) concentrate IV, Heparin cofactor BProducts: KYBERNIN P 500 IU IV ENJEKSİYONLUK İNFÜZYONLUK LİYOFİLİZE TOZ VE ÇÖZÜCÜ, KYBERNIN POxytocin
go.drugbank.com/drugs/DB00107ApprovedInvestigationalVet approved[A229008,A228593] In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recognized with a Nobel prize for his work. … [A229108,A229113] It is estimated that labor induction with oxytocin is used in almost 10% of deliveries globally.
Mixtures: Bakumokon 5% Minoxidil, Bakumokon 7% Minoxidil SulfateCategories: Increased Uterine Smooth Muscle Contraction or ToneZolmitriptan
go.drugbank.com/drugs/DB00315ApprovedInvestigationalIt is currently available in both tablet and nasal spray forms.[L12978] … [A193791] Triptans can be administered alone or in combination with an NSAID like [naproxen], and represent the current "gold standard" for acute migraine treatment.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: (S)-4-({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one, 4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-onealpha-Tocopherol succinate
go.drugbank.com/drugs/DB14001ApprovedNutraceuticalVet approvedIn particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and generally exhibits the greatest … Moreover, although it is generally believed that alpha-tocopherol succinate would naturally demonstrate such general vitamin E-tocopherol pharmacodynamics after undergoing a logical de-esterification in
Mixtures: Ni-C-E-LE Plus, Dialyvite Supreme DCategories: Compounds used in a research, industrial, or household setting, Vitamin ERomosozumab
go.drugbank.com/drugs/DB11866ApprovedInvestigationalRomosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant … Romosozumab prevents bone resorption and induces the formation of bone though it is associated with an increased risk of cardiac death, heart attack, and stroke in one study[L5921,L5924].
Categories: Drugs for Treatment of Bone DiseasesProducts: EVENITY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 105 MG/1.17 ML, EVENITY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 105MG/1.17MLFlupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawn[A229083] Flupentixol is an antagonist of both D1 and D2 dopamine receptors. … It is used for the management of chronic schizophrenia in patients whose main manifestations do not include excitement, agitation or hyperactivity.
Categories: Dopamine D2 Receptor Antagonists, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: Fluanxol Depot 2% -liq Im 20mg/ml, FLUANXOL DEPOT 20MG/ML IM ENJ. SOLUSYON, 1 ADETDexamethasone
go.drugbank.com/drugs/DB01234ApprovedInvestigationalVet approved[L10695] In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms … [L10701] Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone].[A188724] Dexamethasone was granted FDA approval on 30 October 1958.
Mixtures: TOBRAMICINA E DESAMETASONE DOC GENERICI, CLOXONA-OCategories: Corticosteroids, Moderately Potent (Group II), Inducers of Drug Clearance