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Protein C
go.drugbank.com/drugs/DB11312ApprovedInvestigationalProtein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. … A lack of protein C in the body would lead to unchecked coagulation activation, resulting in thrombin generation and intravascular clot formation.
Synonyms: Protein C, Human protein CMixtures: Beriplex P/n 500, Beriplex P/n 1000Antithrombin III human
go.drugbank.com/drugs/DB11598ApprovedInvestigationalA plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Synonyms: Antithrombin III (human) concentrate IV, Heparin cofactor BProducts: KYBERNIN P 500 IU IV ENJEKSİYONLUK İNFÜZYONLUK LİYOFİLİZE TOZ VE ÇÖZÜCÜ, KYBERNIN POxytocin
go.drugbank.com/drugs/DB00107ApprovedInvestigationalVet approved[A229008,A228593] In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recognized with a Nobel prize for his work. … [A229108,A229113] It is estimated that labor induction with oxytocin is used in almost 10% of deliveries globally.
Mixtures: Bakumokon 5% Minoxidil, Bakumokon 7% Minoxidil SulfateCategories: Increased Uterine Smooth Muscle Contraction or ToneZolmitriptan
go.drugbank.com/drugs/DB00315ApprovedInvestigationalIt is currently available in both tablet and nasal spray forms.[L12978] … [A193791] Triptans can be administered alone or in combination with an NSAID like [naproxen], and represent the current "gold standard" for acute migraine treatment.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: (S)-4-({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one, 4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-oneFlupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawn[A229083] Flupentixol is an antagonist of both D1 and D2 dopamine receptors. … It is used for the management of chronic schizophrenia in patients whose main manifestations do not include excitement, agitation or hyperactivity.
Categories: Dopamine D2 Receptor Antagonists, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: Fluanxol Depot 2% -liq Im 20mg/ml, FLUANXOL DEPOT 20MG/ML IM ENJ. SOLUSYON, 1 ADETFremanezumab
go.drugbank.com/drugs/DB14041ApprovedInvestigational[L11749] It was developed by Teva Pharmaceuticals USA and approved by the FDA in September 2018. … Fremanezumab is a humanized monoclonal antibody targeted against human calcitonin gene-related peptide (CGRP) for the prevention of migraine headaches.
Products: AJOVY SOLUTION FOR INJECTION IN PRE-FILLED PEN 225 MG/1.5ML, AJOVY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 225 MG/1.5MLDexamethasone
go.drugbank.com/drugs/DB01234ApprovedInvestigationalVet approved[L10695] In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms … [L10701] Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone].[A188724] Dexamethasone was granted FDA approval on 30 October 1958.
Mixtures: TOBRAMICINA E DESAMETASONE DOC GENERICI, CLOXONA-OCategories: Corticosteroids, Moderately Potent (Group II), Inducers of Drug ClearanceRomosozumab
go.drugbank.com/drugs/DB11866ApprovedInvestigationalRomosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant … Romosozumab prevents bone resorption and induces the formation of bone though it is associated with an increased risk of cardiac death, heart attack, and stroke in one study[L5921,L5924].
Categories: Drugs for Treatment of Bone DiseasesProducts: EVENITY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 105 MG/1.17 ML, EVENITY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 105MG/1.17MLKetorolac
go.drugbank.com/drugs/DB00465ApprovedInvestigational[L6520] Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.[L6511] … Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.
Mixtures: ONEMER DT, Ixoba MCategories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSOlmesartan
go.drugbank.com/drugs/DB00275ApprovedInvestigationalThe angiotensin II receptor blocker (ARB) family of drugs unique in that it blocks all angiotensin II activity, regardless of where or how it was synthesized. … angiotensin I to angiotensin II through inhibition of the ACE enzyme.
Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid, 4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acidMixtures: OLMEPRESS D, OLMEDIPIN ® D 20/12.5 TABLETA RECUBIERTA